Amlodipine Besylate

Objective To prepare amlodipine besylate tablets and to establish the quality standard.

目的制备苯磺酸氨氯地平片,制订其质量标准.

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Objective To observe the effect of telmisartan and amlodipine besylate tablet coalescent action to renal hypertension and function.

目的观察替米沙坦和苯磺酸氨氯地平片联合用药对肾性高血压和肾功能的影响。

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Conclusion The methods of identification, check and quantitative determination are simple, accurate, reproducible and highly selective. They can control the quality of amlodipine besylate tablets validly.

结论处方设计合理，测定方法操作方便，结果准确，重现性好，能有效地控制苯磺酸氨氯地平片的质量。

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Norvasc Amlodipine Besylate Molecular formula: C26H31ClN2O8S Properties: white or light yellow crystalline powder, odorless, bitter taste, soluble in water, methanol.

络活喜Amlodipine Besylate分子式：C26H31ClN2O8S性质：白色或淡黄色结晶性粉未，无臭、味苦，易溶于水、甲醇。

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Compared with the results from HPLC, the relative errors ( RE%) of amlodipine besylate were less than 2.53%. The analytical results could be applied to qualitative control of Norvasc in tablets for practical manufacture.

用HPLC法的测定结果作标准，苯磺酸氨氯地平预测值的相对误差RE（%）<2.53%，可以满足Norvasc药片实际生产中的质量控制要求。

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The trough to peak ratios for SBP and DBP were 70% and 72% separately in amlodipine mesylate group, while those of amlodipine besylate were 66% and 69%.

甲磺酸氨氯地平组收缩压和舒张压的24h降压谷/峰比分别为70%和72%；苯磺酸氨氯地平组分别为66%和69%。

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The improved partial least squares ( PLS) method was used to analyze the near infrared ( NIR) reflectance spectrum of norvasc in tablets. The contents of amlodipine besylate, which exist in Norvasc medicine, have been accurately nondestructive quantitatively predicted.

本文用改进的偏最小二乘法（PLS）解析Norvasc药片的近红外（NIR）漫反射光谱，实现了对其中的有效成分苯磺酸氨氯地平的精确的非破坏定量分析。

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Amlodipine besylate and atorvastatin calcium for treating patients with hypertension and hyperlipemia A shortage of calcium might also contribute to the rise in blood pressure that commonly accompanies aging.

氨氯地平联用阿托伐他汀钙治疗高血压伴高血脂29例临床观察缺钙还可能促成通常因年老而出现的血压升高。

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